A few years ago, arthritis patients and their doctors found out the hard way that boosting levels of the hormone leptin produced harsh unintended consequences.
For one thing, leptin nearly destroyed the patients’ joints, triggering a great deal of unnecessary pain.
To make matters worse, these arthritis patients were taking leptin to try and lose weight since it’s the hormone that signals to your brain when you’re full and should stop eating.
On paper, it’s a great idea: If you boost your leptin levels, you won’t be hungry, you’ll eat less, and you’ll lose weight.
Unfortunately, that’s not what happened. As it turns out, an uncommonly high leptin level triggers leptin resistance, which makes people feel even hungrier and drives them to eat in excess.
So two unintended consequences — weight gain and arthritis pain — brought supplemental leptin down in flames.
But there was an upside to this experiment — one more unintended consequence with a silver lining for arthritis patients: Researchers discovered that when leptin levels are in the perfect balance, arthritis patients experience significant pain relief.
This is what we’ve learned thus far about leptin over the past 20 years. And it’s not the end of the leptin story — or its dangers…
The unexpected metabolic culprit
As Dr. Fred Pescatore points out in his Pain-Free Life Protocol, yet another important leptin factor opens up a new area of concern.
Recent research reveals that leptin also puts you at risk of developing metabolic syndrome — the threatening pre-diabetic condition characterized by high blood sugar, weight gain (especially in the abdomen), high blood pressure, and other red flags.
Dr. Pescatore elaborates: “I can tell you that my patients who are overweight and have metabolic syndrome also have more arthritis pain. In fact, they turn up hand-in-hand so often that I started considering joint pain to be a fifth symptom of metabolic syndrome.
“Now we have proof that leptin is the culprit in this unexpected conjunction.”
Dr. Pescatore cites a study review that analyzed 11 clinical trials. Researchers concluded that leptin lays the groundwork for a host of serious health concerns, including:
- Faster cartilage thinning — transforming it from thick and springy, to weak and brittle
- Higher risk of cardiovascular disease
- Higher risk of some cancers
- Increased wear and tear on your joint “cushions,” including synovial fluid and hyaluronic acid
- More inflammation
- More severe arthritis symptoms
He says, “It’s mind-boggling how many areas of health could be sabotaged by out-of-control leptin. And there’s some evidence that these effects could be even worse for women.”
Comfort, mobility, and cartilage support
In Dr. Pescatore’s view, balancing out your leptin is one of the most effective steps you can take to resolve chronic inflammation, improve cushioning in your joints, strengthen mobility, and give yourself a significant reduction in joint pain.
The most direct method for balancing leptin takes us back to square one: weight loss. Dr. Pescatore explains why: “When you shrink fat cells you’re cutting off leptin right at the source. I know it can be hard. But you’ll feel a huge difference almost right away. In fact, losing 20 percent of your body weight can cut your pain symptoms in half.”
Beyond weight loss, arthritis patients can find relief from excess leptin with natural compounds called glycosaminoglycans, or GAGs, which Dr. Pescatore calls “your next big pain-fighting breakthrough.”
He explains that GAGs work in two important ways…
- They help keep cartilage flexible
- They’re clinically tested to fight leptin directly in your joints
To boost GAGs, Dr. Pescatore recommends a supplement with an odd name: green lipped mussel extract.
Even though this unique type of shellfish is found exclusively off the coast of New Zealand, Dr. Pescatore notes that it’s one of the most researched supplements in all of natural medicine.
In one study, researchers found that 1,500 milligrams of green lipped muscle extract daily improved joint comfort, mobility, and stiffness in 3 out of 4 participants.
In another clinical trial, more than 80 percent of participants who used 1,500 mg of the extract for a year reported greater mobility, improved joint comfort, and greater ease in exercise. X-rays also showed that the supplement promotes cartilage growth.
Dr. Pescatore recommends 1,000 mg of green lipped muscle extract daily, along with one more GAG-rich supplement.
You can find more details about it, as well as his personal recommendations, in the Resource Directory of his Pain-Free Life Protocol.